Membrane lipids are key-modulators of the Membrane lipids are key-modulators of the endocannabinoid-hydrolase FAAH Enrico Dainese1,2¥*, Gianni De Fabritiis3¥,Annalaura Sabatucci1, Sergio Oddi1,2, Clotilde Beatrice Angelucci 1, Chiara Di Pancrazio , Toni Giorgino4, Nathaniel Stanley3, Michele Del Carlo5, Benjamin Cravatt6 and Mauro Maccarrone2,7* Development of a Multiplexed Activity-Based Protein Profiling A multiplexed ABPP assay was developed in which a probe cocktail of FP-BODIPY and MB064 visualized most endocannabinoid serine hydrolases in mouse brain proteomes in a single experiment. The multiplexed ABPP assay was employed to profile endocannabinoid hydrolase inhibitor activity and selectivity in the mouse brain. Uri: Manipulation of the Endocannabinoid System in Colitis: A A significant increase in FAAH activity was observed in croton oil–treated mice, 11 but in contrast, FAAH mRNA expression is significantly reduced in early stages of inflammation and returned to normal levels over time in multiple colitis models. 30, 35 In addition to the previously reviewed effects of α,β-amyrin as an anti-inflammatory

Niphakis et al (2012) O-hydroxyacetamide carbamates as a highly potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci.

A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. The Cravatt Lab - Scripps Research Institute Niphakis MJ, Cognetta AB, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF. (2013) Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2013 Jun 3. [Epub ahead of print] Chang JW, Cognetta AB 3rd, Niphakis MJ, Cravatt BF. (2013) Proteome-Wide

Itch and pain are two irritating sensations sharing a lot in common. Considering the antinociceptive effects of blockade of endocannabinoid degrading enzymes in pain states, we attempted to reduce scratching behavior by endocannabinoid modulation …

Development and characterization of endocannabinoid hydrolases @article{Morera2012DevelopmentAC, title={Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.}, author={Ludovica Morera and Geoffray Labar and Giorgio Ortar and Didier M. Lambert}, journal={Bioorganic & medicinal Membrane lipids are key modulators of the Enrico Dainese, Gianni De Fabritiis, Annalaura Sabatucci, Sergio Oddi, Clotilde Beatrice Angelucci, Chiara Di Pancrazio, Toni Giorgino, Nathaniel Stanley, Michele Del Carlo, Benjamin F. Cravatt, Mauro Maccarrone; Membrane lipids are key modulators of the endocannabinoid-hydrolase FAAH.

Chemical probes of endocannabinoid metabolism. | Sigma-Aldrich

Attenuation of serotonin-induced itch responses by inhibition of